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The absorption and systemic metabolism of 5-aminosalicylic acid (5-ASA) were investigated in nine healthy adult volunteers using a crossover design. Each subject received 200 mg of 5-ASA in oral and rectal doses. There was a 2-hour washout between the two routes. Following oral administration the peak concentration was reached in 0.5 hour (range: 0.3-1.0) and the bioavailability ranged from 26 to 50%. The pharmacokinetics of 5-ASA after rectal administration were comparable to those of the oral dose, but rectal absorption of the drug was slower. The peak concentration was reached at 2.0 hour after the rectal dose (range: 1.2-3.0) and bioavailability was 64%. The results of the pharmacokinetic analysis showed that the differences observed after the oral and rectal administration were due to differences in bioavailability, and not to differences in pharmacokinetics. The systemic metabolism of 5-ASA was assessed after oral administration and ranged from 11 to 28% of the administered dose. Urinary excretion of 5-ASA, the only metabolite detected, was 9.2-11.6% of the oral dose.Shuffling genes
The quest for the ultimate cancer-killer
In a broad sense, scientists have long tried to find ways to direct our own cells to self-destruct. The so-called suicide genes, which are designed to carry out this process, are, in effect, genes that can instruct cells to commit suicide. Cancer cells, of course, contain normal genes — and suicide genes have long been explored as a way to distinguish healthy cells from cancerous ones. In the case of the cellular version of the AIDS virus, HIV, the addition of suicide genes is being explored as a way to kill HIV-infected cells and to leave healthy cells alone.
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AutoCAD 20.1 With Product Key Free Download
Change the component key on an existing component
> Change the component key on an existing component
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A new workflow for your designs:
Create new drawings quickly from markups of designs you created in AutoCAD. (video: 2:30 min.)
Show your best work and connect with friends, workmates and colleagues. Share your most important projects, and provide feedback on their progress.
Bring your designs to life faster with smart dimension lines and annotation tools. Now, AutoCAD can automatically create and add dimension lines to your drawings, based on the values you chose for the dimension units and separations, such as 1/8 in. (video: 0:51 min.)
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AutoCAD Integration |
Bug Fixes |
New Features |
API Changes |
Automatic generation of 2D measurements
Open a 2D measurement tool and automatically create dimensions. In addition, you can import a standard or custom 2D pattern from a database. (video: 3:50 min.)
Import to AutoCAD
Import and convert a shapefile to a series of 2D or 3D objects in AutoCAD. (video: 3:36 min.)
For more information, see the new Quick Help that can be displayed when you select the 2D or 3D measurement tool.
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A new technique for distance measurement is available. With this technique, you can measure
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The game will not run if you do not have the ability to play CD-Rom games or the disk is not mounted.
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